<p>Some bacteria, including <taxon tax_id="90371">Salmonella enterica subsp. enterica serovar Typhimurium</taxon>, degrade 1,2-propanediol by a pathway that requires coenzyme B12, adenosylcobalamin (AdoCbl). Bacteria that harbour this pathway can use propanediol as a sole carbon and energy source. Proteins required for 1,2-propanediol degradation are encoded by the <i>pdu</i> operon [<cite idref="PUB00011184"/>]. Members of this family belong to the GHMP kinase domain superfamily (and are distantly related to galactokinase, L-homoserine kinase, and mevalonate kinase). Since cobalamin biosynthesis requires L-threonine-3P as a substrate for the CobD aminotransferase, and the genome context analysis predicts that PduX is cobalamin biosynthesis-related, it has been suggested that PduX functions in the propanediol degradation pathway as L-threonine kinase [<cite idref="PUB00015657"/>].</p> Propanediol utilisation/coumermycin biosynthesis, PduX-related